Cargando…

Functional Characterization of a Chimeric Soluble Fas Ligand Polymer with In Vivo Anti-Tumor Activity

Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daburon, Sophie, Devaud, Christel, Costet, Pierre, Morello, Aurore, Garrigue-Antar, Laure, Maillasson, Mike, Hargous, Nathalie, Lapaillerie, Delphine, Bonneu, Marc, Dechanet-Merville, Julie, Legembre, Patrick, Capone, Myriam, Moreau, Jean-François, Taupin, Jean-Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541234/ https://www.ncbi.nlm.nih.gov/pubmed/23326557 http://dx.doi.org/10.1371/journal.pone.0054000

Ejemplares similares

Enhancing Production and Cytotoxic Activity of Polymeric Soluble FasL-Based Chimeric Proteins by Concomitant Expression of Soluble FasL
por: Morello, Aurore, et al.
Publicado: (2013)

Precise Mapping of the CD95 Pre-Ligand Assembly Domain
por: Edmond, Valérie, et al.
Publicado: (2012)

γδ T Cell-Mediated Immunity to Cytomegalovirus Infection
por: Khairallah, Camille, et al.
Publicado: (2017)

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)
por: Khairallah, Camille, et al.
Publicado: (2015)

Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation
por: Couzi, Lionel, et al.
Publicado: (2015)

TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance
por: Guerville, Florent, et al.
Publicado: (2015)

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
por: Lawand, Myriam, et al.
Publicado: (2017)

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
por: Guégan, Jean-Philippe, et al.
Publicado: (2021)

Editorial: “Recent Advances in Gamma/Delta T Cell Biology: New Ligands, New Functions, and New Translational Perspectives”
por: Kabelitz, Dieter, et al.
Publicado: (2015)

Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA
por: Hisaka, Toru, et al.
Publicado: (2004)

Shared reactivity of Vδ2(neg) γδ T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells
por: Halary, Franck, et al.
Publicado: (2005)

CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases
por: Le Gallo, Matthieu, et al.
Publicado: (2017)

Uncovering the Anticancer Potential of Murine Cytomegalovirus against Human Colon Cancer Cells
por: Massara, Layal, et al.
Publicado: (2020)

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors
por: Galli, Gael, et al.
Publicado: (2022)

Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice
por: Yong, Carmen S. M., et al.
Publicado: (2015)

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer
por: Yong, Carmen S.M., et al.
Publicado: (2016)

Engineering T Cell Function Using Chimeric Antigen Receptors Identified Using a DNA Library Approach
por: Duong, Connie P. M., et al.
Publicado: (2013)

The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway
por: Tauzin, Sébastien, et al.
Publicado: (2011)

Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway
por: Tauzin, Sébastien, et al.
Publicado: (2019)

Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway
por: Tauzin, Sébastien, et al.
Publicado: (2023)

Preclinical and Clinical Immunotherapeutic Strategies in Epithelial Ovarian Cancer
por: Martinez, Alejandra, et al.
Publicado: (2020)

Fas and Mutant Estrogen Receptor Chimeric Gene: A Novel Suicide Vector for Tamoxifen‐inducible Apoptosis
por: Kodaira, Hiroshi, et al.
Publicado: (1998)

Human Vγ9Vδ2 T Lymphocytes in the Immune Response to P. falciparum Infection
por: Howard, Jennifer, et al.
Publicado: (2018)

The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility
por: Monet, Michael, et al.
Publicado: (2016)

Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells
por: Guenot, Marianne, et al.
Publicado: (2015)

The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
por: Henkler, Frank, et al.
Publicado: (2005)

The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy
por: Chauveau, Bertrand, et al.
Publicado: (2022)

Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review
por: Guerville, Florent, et al.
Publicado: (2022)

WARS1, TYMP and GBP1 display a distinctive microcirculation pattern by immunohistochemistry during antibody-mediated rejection in kidney transplantation
por: Chauveau, Bertrand, et al.
Publicado: (2022)

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
Publicado: (1996)

Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus
por: Vincent, Fabien B, et al.
Publicado: (2020)

Understanding the role of Fas-Fas ligand system in bone
por: Marusic, Ana, et al.
Publicado: (2012)

Differential expressions of Fas and Fas ligand in human placenta.
por: Roh, Cheong-Rae, et al.
Publicado: (2002)

Soluble Fas and the −670 Polymorphism of Fas in Lupus Nephritis
por: Bollain-y-Goytia, Juan José, et al.
Publicado: (2014)

The Fas/FasL System in Reproduction: Survival and Apoptosis
por: Mor, Gil, et al.
Publicado: (2002)

CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
por: Qadir, Abdul S., et al.
Publicado: (2021)

Fas and Fas Ligand Interactions Suppress Melanoma Lung Metastasis
por: Owen-Schaub, Laurie B., et al.
Publicado: (1998)

Apoptosis role of FAS/FAS ligand system in the regulation of myelopoiesis.
por: Alenzi, Faris Q., et al.
Publicado: (2005)

Role of the Fas/FasL pathway in HIV or SIV disease
por: Poonia, Bhawna, et al.
Publicado: (2009)

Prognostic value of the Fas/Fas ligand system in breast cancer
por: Bębenek, Marek, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_s2kt4gbkfmqoccu7dabo7vh1vg