Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes

BACKGROUND: Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate chondroyctes suggesting that FGFR3 reduces proliferat...

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Detalles Bibliográficos
Autores principales: Smith, Logan B, Belanger, Janelle M, Oberbauer, Anita M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541258/
https://www.ncbi.nlm.nih.gov/pubmed/23216972
http://dx.doi.org/10.1186/2049-1891-3-39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541258/
https://www.ncbi.nlm.nih.gov/pubmed/23216972
http://dx.doi.org/10.1186/2049-1891-3-39

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