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Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes

BACKGROUND: Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate chondroyctes suggesting that FGFR3 reduces proliferat...

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Detalles Bibliográficos
Autores principales:	Smith, Logan B, Belanger, Janelle M, Oberbauer, Anita M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541258/ https://www.ncbi.nlm.nih.gov/pubmed/23216972 http://dx.doi.org/10.1186/2049-1891-3-39

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