OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability

BACKGROUND: Mitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot–Marie–Tooth disease and dominant optic atrophy. Previously we reported that the fusion protein optic atrophy 1 (OPA1) is decreased in heart failure. METHODS AND RESULTS: We investigated cardiac f...

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Detalles Bibliográficos
Autores principales: Chen, Le, Liu, Tingting, Tran, Alice, Lu, Xiyuan, Tomilov, Alexey A., Davies, Vanessa, Cortopassi, Gino, Chiamvimonvat, Nipavan, Bers, Donald M., Votruba, Marcela, Knowlton, Anne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541627/
https://www.ncbi.nlm.nih.gov/pubmed/23316298
http://dx.doi.org/10.1161/JAHA.112.003012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541627/
https://www.ncbi.nlm.nih.gov/pubmed/23316298
http://dx.doi.org/10.1161/JAHA.112.003012

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