Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised

The Escherichia coli-infecting bacteriophage T7 encodes a 7 kDa protein, called Gp2, which is a potent inhibitor of the host RNA polymerase (RNAp). Gp2 is essential for T7 phage development. The interaction site for Gp2 on the E. coli RNAp is the β′ jaw domain, which is part of the DNA binding chann...

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Detalles Bibliográficos
Autores principales: Shadrin, Andrey, Sheppard, Carol, Severinov, Konstantin, Matthews, Steve, Wigneshweraraj, Sivaramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2012
Materias:
Cell and Molecular Biology of Microbes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541766/
https://www.ncbi.nlm.nih.gov/pubmed/22977089
http://dx.doi.org/10.1099/mic.0.062547-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541766/
https://www.ncbi.nlm.nih.gov/pubmed/22977089
http://dx.doi.org/10.1099/mic.0.062547-0

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