An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo

Influenza viruses readily mutate by accumulating point mutations and also by reassortment in which they acquire whole gene segments from another virus in a co-infected host. The NS1 gene is a major virulence factor of influenza A virus. The effects of changes in NS1 sequence depend on the influenza...

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Detalles Bibliográficos
Autores principales: Shelton, Holly, Smith, Matt, Hartgroves, Lorian, Stilwell, Peter, Roberts, Kim, Johnson, Ben, Barclay, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2012
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541804/
https://www.ncbi.nlm.nih.gov/pubmed/22323532
http://dx.doi.org/10.1099/vir.0.039701-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541804/
https://www.ncbi.nlm.nih.gov/pubmed/22323532
http://dx.doi.org/10.1099/vir.0.039701-0

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