Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy

Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated...

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Detalles Bibliográficos
Autores principales: Shi, SongTing, de Gorter, David J. J., Hoogaars, Willem M. H., ’t Hoen, Peter A. C., ten Dijke, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541930/
https://www.ncbi.nlm.nih.gov/pubmed/22752156
http://dx.doi.org/10.1007/s00018-012-1054-x
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author Shi, SongTing
de Gorter, David J. J.
Hoogaars, Willem M. H.
’t Hoen, Peter A. C.
ten Dijke, Peter
author_facet Shi, SongTing
de Gorter, David J. J.
Hoogaars, Willem M. H.
’t Hoen, Peter A. C.
ten Dijke, Peter
author_sort Shi, SongTing
collection PubMed
description Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this review, we will summarize the recent progress in elucidation of BMP signal transduction, how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy, and discuss possible therapeutic strategies for treatment of these diseases.
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spelling pubmed-35419302013-01-11 Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy Shi, SongTing de Gorter, David J. J. Hoogaars, Willem M. H. ’t Hoen, Peter A. C. ten Dijke, Peter Cell Mol Life Sci Review Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this review, we will summarize the recent progress in elucidation of BMP signal transduction, how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy, and discuss possible therapeutic strategies for treatment of these diseases. SP Birkhäuser Verlag Basel 2012-07-04 2013 /pmc/articles/PMC3541930/ /pubmed/22752156 http://dx.doi.org/10.1007/s00018-012-1054-x Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Shi, SongTing
de Gorter, David J. J.
Hoogaars, Willem M. H.
’t Hoen, Peter A. C.
ten Dijke, Peter
Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
title Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
title_full Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
title_fullStr Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
title_full_unstemmed Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
title_short Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy
title_sort overactive bone morphogenetic protein signaling in heterotopic ossification and duchenne muscular dystrophy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541930/
https://www.ncbi.nlm.nih.gov/pubmed/22752156
http://dx.doi.org/10.1007/s00018-012-1054-x
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