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Decoupling nutrient signaling from growth rate causes aerobic glycolysis and deregulation of cell size and gene expression
To survive and proliferate, cells need to coordinate their metabolism, gene expression, and cell division. To understand this coordination and the consequences of its failure, we uncoupled biomass synthesis from nutrient signaling by growing, in chemostats, yeast auxotrophs for histidine, lysine, or...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The American Society for Cell Biology
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541962/ https://www.ncbi.nlm.nih.gov/pubmed/23135997 http://dx.doi.org/10.1091/mbc.E12-09-0670 |