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Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model

BACKGROUND: Despite significant nephrotoxicity, calcineurin inhibitors (CNIs) remain the cornerstone of immunosuppression in solid organ transplantation. We, along with others, have reported tolerogenic properties of anti-thymocyte globulin (ATG, Thymoglobulin®), evinced by its ability both to spare...

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Detalles Bibliográficos
Autores principales: D’Addio, Francesca, Boenisch, Olaf, Magee, Ciara N., Yeung, Melissa Y., Yuan, Xueli, Mfarrej, Bechara, Vergani, Andrea, Ansari, Mohammed Javeed, Fiorina, Paolo, Najafian, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542267/
https://www.ncbi.nlm.nih.gov/pubmed/23326509
http://dx.doi.org/10.1371/journal.pone.0053797