Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation

The majority of patients with systemic mastocytosis exhibit a D816V mutation in the activating loop of the Kit receptor expressed on mast cells. The Kit ligand regulates mast cell survival by transcriptional repression of the proapoptotic BH3-only protein Bim and by promoting Bim phosphorylation tha...

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Detalles Bibliográficos
Autores principales: Möller Westerberg, C, Hägglund, H, Nilsson, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542593/
https://www.ncbi.nlm.nih.gov/pubmed/23152053
http://dx.doi.org/10.1038/cddis.2012.157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542593/
https://www.ncbi.nlm.nih.gov/pubmed/23152053
http://dx.doi.org/10.1038/cddis.2012.157

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