USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

Type 1 diabetes (T1D) is an autoimmune disease targeting pancreatic beta cells. Genome-wide association studies and gene expression analysis identified interferon (IFN)-driven gene networks as crucial pathways in the pathogenesis of T1D. IFNs are linked to the response to viral infections and might...

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Detalles Bibliográficos
Autores principales: Santin, I, Moore, F, Grieco, F A, Marchetti, P, Brancolini, C, Eizirik, D L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542594/
https://www.ncbi.nlm.nih.gov/pubmed/23152055
http://dx.doi.org/10.1038/cddis.2012.158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542594/
https://www.ncbi.nlm.nih.gov/pubmed/23152055
http://dx.doi.org/10.1038/cddis.2012.158

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