Cargando…

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

Type 1 diabetes (T1D) is an autoimmune disease targeting pancreatic beta cells. Genome-wide association studies and gene expression analysis identified interferon (IFN)-driven gene networks as crucial pathways in the pathogenesis of T1D. IFNs are linked to the response to viral infections and might...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santin, I, Moore, F, Grieco, F A, Marchetti, P, Brancolini, C, Eizirik, D L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542594/ https://www.ncbi.nlm.nih.gov/pubmed/23152055 http://dx.doi.org/10.1038/cddis.2012.158

Ejemplares similares

The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells
por: Moore, Fabrice, et al.
Publicado: (2012)

Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
por: Coomans de Brachène, Alexandra, et al.
Publicado: (2021)

USP18 – a multifunctional component in the interferon response
por: Basters, Anja, et al.
Publicado: (2018)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells
por: Gurzov, Esteban N., et al.
Publicado: (2008)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
por: Moore, Fabrice, et al.
Publicado: (2009)

USP18 Mediates Interferon Resistance of Dengue Virus Infection
por: Ye, Haiyan, et al.
Publicado: (2021)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2012)

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes
por: Marroqui, Laura, et al.
Publicado: (2015)

ISGylation-independent protection of cell growth by USP18 following interferon stimulation
por: Clancy, Anne, et al.
Publicado: (2023)

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling
por: Arimoto, Kei-ichiro, et al.
Publicado: (2017)

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
por: Miani, M, et al.
Publicado: (2013)

Nova1 is a master regulator of alternative splicing in pancreatic beta cells
por: Villate, Olatz, et al.
Publicado: (2014)

Multiple functions of USP18
por: Honke, Nadine, et al.
Publicado: (2016)

Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
por: Arimoto, Kei-ichiro, et al.
Publicado: (2023)

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
por: François-Newton, Véronique, et al.
Publicado: (2011)

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
por: Colli, Maikel L., et al.
Publicado: (2020)

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
por: Brozzi, Flora, et al.
Publicado: (2016)

Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression
por: MacParland, Sonya A., et al.
Publicado: (2016)

A partial form of inherited human USP18 deficiency underlies infection and inflammation
por: Martin-Fernandez, Marta, et al.
Publicado: (2022)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
por: Nogueira, Tatiane C., et al.
Publicado: (2013)

Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer
por: Blaauboer, Amber, et al.
Publicado: (2020)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
por: Szymczak, Florian, et al.
Publicado: (2022)

Detailed transcriptome atlas of the pancreatic beta cell
por: Kutlu, Burak, et al.
Publicado: (2009)

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes
por: Bugliani, M., et al.
Publicado: (2019)

Usp18 Driven Enforced Viral Replication in Dendritic Cells Contributes to Break of Immunological Tolerance in Autoimmune Diabetes
por: Honke, Nadine, et al.
Publicado: (2013)

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis
por: Magnusson, Nils E, et al.
Publicado: (2005)

Structural basis of the specificity of USP18 toward ISG15
por: Basters, Anja, et al.
Publicado: (2017)

Targeting melanoma residual disease by USP7
por: Vishnoi, Monika, et al.
Publicado: (2018)

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
por: Tyka, Karolina, et al.
Publicado: (2019)

Emerging Roles of USP18: From Biology to Pathophysiology
por: Kang, Ji An, et al.
Publicado: (2020)

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response
por: Gorrepati, Kanaka Durga Devi, et al.
Publicado: (2018)

Deubiquitinase USP18 promotes the progression of pancreatic cancer via enhancing the Notch1-c-Myc axis
por: Feng, Long, et al.
Publicado: (2020)

Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2–USP5 interactions in the pain pathway
por: Stemkowski, Patrick L, et al.
Publicado: (2017)

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis
por: Størling, Joachim, et al.
Publicado: (2017)

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
por: Nelson, Jessica K., et al.
Publicado: (2022)

USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway
por: Diao, Wenjing, et al.
Publicado: (2020)

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas
por: Chinyengetere, Fadzai, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d800br7pf8cn6am97p51f6r2lb