Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens

Metastatic malignant melanoma is highly resistant to chemotherapy, and the average survival rate is under 1 year. The only FDA-approved conventional chemotherapy (i.e., dacarbazine) targets melanoma tumor cells by inducing a form of cell death referred to as apoptosis. However, dacarbazine exhibits...

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Detalles Bibliográficos
Autores principales: Anvekar, R A, Asciolla, J J, Lopez-Rivera, E, Floros, K V, Izadmehr, S, Elkholi, R, Belbin, G, Sikora, A G, Chipuk, J E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542597/
https://www.ncbi.nlm.nih.gov/pubmed/23152056
http://dx.doi.org/10.1038/cddis.2012.161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542597/
https://www.ncbi.nlm.nih.gov/pubmed/23152056
http://dx.doi.org/10.1038/cddis.2012.161

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