Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells

The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing one of the mechanisms of resistance to therapies. Therefore, the identification of inhibito...

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Detalles Bibliográficos
Autores principales: Folgiero, V, Di Carlo, S E, Bon, G, Spugnini, E P, Di Benedetto, A, Germoni, S, Pia Gentileschi, M, Accardo, A, Milella, M, Morelli, G, Bossi, G, Mottolese, M, Falcioni, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542615/
https://www.ncbi.nlm.nih.gov/pubmed/23222510
http://dx.doi.org/10.1038/cddis.2012.179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542615/
https://www.ncbi.nlm.nih.gov/pubmed/23222510
http://dx.doi.org/10.1038/cddis.2012.179

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