Cargando…

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism

We recently identified Grainyhead-like 2 (GRHL2), a mammalian homolog of Grainyhead in Drosophila, to be a novel transcription factor that regulates hTERT gene expression and enhances proliferation of normal human epidermal keratinocytes (NHEK). In the current study, we show that GRHL2 impairs kerat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, W, Xiao Liu, Z, Oh, J-E, Shin, K-H, Kim, R H, Jiang, M, Park, N-H, Kang, M K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542624/ https://www.ncbi.nlm.nih.gov/pubmed/23254293 http://dx.doi.org/10.1038/cddis.2012.190

Ejemplares similares

Grainyhead-like (Grhl) Target Genes in Development and Cancer
por: Gasperoni, Jemma G., et al.
Publicado: (2022)

Grainyhead‐like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression
por: Nishino, Hitoe, et al.
Publicado: (2017)

Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways
por: Chen, Wei, et al.
Publicado: (2018)

Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice
por: De Castro, Sandra C P, et al.
Publicado: (2018)

Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development
por: Goldie, Stephen J., et al.
Publicado: (2016)

Role of grainyhead-like 2 in the formation of functional tight junctions
por: Tanimizu, Naoki, et al.
Publicado: (2013)

Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial–mesenchymal transition
por: Pifer, Phillip M., et al.
Publicado: (2016)

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
por: Goldie, Stephen J., et al.
Publicado: (2018)

Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer
por: Xiang, J, et al.
Publicado: (2017)

Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer
por: Quan, Yingjun, et al.
Publicado: (2015)

Interferon Regulatory Factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3
por: de la Garza, Gabriel, et al.
Publicado: (2012)

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states
por: Klein, Rachel Herndon, et al.
Publicado: (2017)

The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells
por: Chung, Vin Yee, et al.
Publicado: (2019)

Grainyhead-Like 3 Influences Migration and Invasion of Urothelial Carcinoma Cells
por: Wezel, Felix, et al.
Publicado: (2021)

Overexpression of grainyhead-like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma
por: Wang, Gang, et al.
Publicado: (2019)

Expression and significance of GRHL2 in esophageal cancer
por: Shao, Chengcheng, et al.
Publicado: (2017)

Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues
por: De Castro, Sandra C.P., et al.
Publicado: (2018)

Grainyhead-Like Genes Family May Act as Novel Biomarkers in Colon Cancer
por: Yuan, Minchi, et al.
Publicado: (2020)

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family
por: Ming, Qianqian, et al.
Publicado: (2018)

GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization
por: Kashgari, Ghaidaa, et al.
Publicado: (2021)

Enhancing Transcriptional Reprogramming of Mesenchymal Glioblastoma with Grainyhead-like 2 and HDAC Inhibitors Leads to Apoptosis and Cell-Cycle Dysregulation
por: Kotian, Spandana, et al.
Publicado: (2023)

GRHL2-controlled gene expression networks in luminal breast cancer
por: Wang, Zi, et al.
Publicado: (2023)

Grainyhead-like 2 is required for morphological integrity of mouse embryonic stem cells and orderly formation of inner ear-like organoids
por: Forrester-Gauntlett, Blaise, et al.
Publicado: (2023)

Confirmation of GRHL2 as the gene for the DFNA28 locus
por: Vona, Barbara, et al.
Publicado: (2013)

Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2
por: Xu, M, et al.
Publicado: (2016)

Association of polymorphisms in grainyhead-like-2 gene with the susceptibility to age-related hearing loss: A systematic review and meta-analysis
por: Han, Baoai, et al.
Publicado: (2019)

THU491 GRHL2 Overexpression In Breast Cancer Progression
por: Zheng, Christy, et al.
Publicado: (2023)

Grainyhead like 3 – a newly identified TNFalpha regulated transcription factor – is regulated by the Src kinases & NO
por: Lukosz, M, et al.
Publicado: (2009)

Mutations in GRHL2 Result in an Autosomal-Recessive Ectodermal Dysplasia Syndrome
por: Petrof, Gabriela, et al.
Publicado: (2014)

Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers
por: Kikulska, Agnieszka, et al.
Publicado: (2018)

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes
por: Kotarba, Grzegorz, et al.
Publicado: (2021)

The Transcriptional Function of GRHL2 in Hormone-Dependent Breast Cancers
por: Reese, Rebecca, et al.
Publicado: (2021)

GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells
por: Gao, Xia, et al.
Publicado: (2015)

Extra-Nuclear Functions of the Transcription Factor Grainyhead-Like 3 in the Endothelium—Interaction with Endothelial Nitric Oxide Synthase
por: Jander, Kirsten, et al.
Publicado: (2021)

Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells
por: Kang, Xuedong, et al.
Publicado: (2008)

GRHL2 Regulation of Growth/Motility Balance in Luminal versus Basal Breast Cancer
por: Wang, Zi, et al.
Publicado: (2023)

Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways
por: Mathiyalagan, Nishanthi, et al.
Publicado: (2019)

Abnormal GRHL2 Methylation Confers Malignant Progression to Acute Leukemia
por: Hua, Jing, et al.
Publicado: (2022)

Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
por: Chen, Xin, et al.
Publicado: (2021)

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension
por: Miles, Lee B., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rktvs0kiqvug7kdpe9n9e5r9f5