TGF-β induces the expression of Nedd4 family-interacting protein 1 (Ndfip1) to silence IL-4 production during iT(reg) cell differentiation

Mice deficient for the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that these animals contain fewer inducible regulatory (iT(reg)) cells. In vitro, Ndfip1-deficient T cells express normal levels of the transcription factor Foxp3 during the first 48 ho...

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Detalles Bibliográficos
Autores principales: Beal, Allison M., Ramos-Hernández, Natalia, Riling, Chris R., Nowelsky, Erin A., Oliver, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542978/
https://www.ncbi.nlm.nih.gov/pubmed/22080920
http://dx.doi.org/10.1038/ni.2154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542978/
https://www.ncbi.nlm.nih.gov/pubmed/22080920
http://dx.doi.org/10.1038/ni.2154

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