Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model

BACKGROUND: Trifunctional bispecific antibodies (trAb) are a special class of bispecific molecules recruiting and activating T cells and accessory immune cells simultaneously at the targeted tumor. The new trAb Ektomab that targets the melanoma-associated ganglioside antigen GD2 and the signaling mo...

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Detalles Bibliográficos
Autores principales: Ruf, Peter, Schäfer, Beatrix, Eissler, Nina, Mocikat, Ralph, Hess, Juergen, Plöscher, Matthias, Wosch, Susanne, Suckstorff, Ivonne, Zehetmeier, Christine, Lindhofer, Horst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543252/
https://www.ncbi.nlm.nih.gov/pubmed/23134699
http://dx.doi.org/10.1186/1479-5876-10-219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543252/
https://www.ncbi.nlm.nih.gov/pubmed/23134699
http://dx.doi.org/10.1186/1479-5876-10-219

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