Structural Insight into DFMO Resistant Ornithine Decarboxylase from Entamoeba histolytica: An Inkling to Adaptive Evolution

BACKGROUND: Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc. α-Difluoromethylornithine (DFMO), a potent drug used for the treatment of African sleeping sickness is an irreversible...

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Detalles Bibliográficos
Autores principales: Preeti, Tapas, Satya, Kumar, Pravindra, Madhubala, Rentala, Tomar, Shailly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543441/
https://www.ncbi.nlm.nih.gov/pubmed/23326423
http://dx.doi.org/10.1371/journal.pone.0053397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543441/
https://www.ncbi.nlm.nih.gov/pubmed/23326423
http://dx.doi.org/10.1371/journal.pone.0053397

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