Cargando…

Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB

Triptolide (TPL) inhibits the proliferation of a variety of cancer cells and has been proposed as an effective anticancer agent. In this study, we demonstrate that TPL downregulates HER2 protein expression in oral, ovarian, and breast cancer cells. It suppresses HER2 protein expression in a dose- an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ou, Chien-Chih, Chen, Yuan-Wu, Hsu, Shih-Chung, Sytwu, Huey-Kang, Loh, Shih-Hurng, Li, Jhy-Wei, Liu, Jah-Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543825/ https://www.ncbi.nlm.nih.gov/pubmed/23346199 http://dx.doi.org/10.1155/2012/350239

Ejemplares similares

Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells
por: Yang, Cheng-Yu, et al.
Publicado: (2016)

Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway
por: Kuo, Han-Peng, et al.
Publicado: (2013)

A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers
por: Lee, Yi-Jen, et al.
Publicado: (2016)

Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism
por: Zhang, Weiying, et al.
Publicado: (2016)

The Antigastric Cancer Effect of Triptolide is Associated With H19/NF-κB/FLIP Axis
por: Yuan, Weiwei, et al.
Publicado: (2022)

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein
por: Yuan, Ziqiao, et al.
Publicado: (2020)

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
por: Zhao, Hongxi, et al.
Publicado: (2012)

Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B
por: Wang, Ling, et al.
Publicado: (2018)

Differential effects of triptolide and tetrandrine on activation of COX-2, NF-κB, and AP-1 and virus production in dengue virus-infected human lung cells
por: Liou, Jun-Ting, et al.
Publicado: (2008)

Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes
por: JIANG, NING, et al.
Publicado: (2016)

Triptolide attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of NF-κB pathway
por: Song, Chundong, et al.
Publicado: (2019)

Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-κB: a study on induced arthritis in rats
por: Xiao, Cheng, et al.
Publicado: (2009)

Foxp3 Represses Retroviral Transcription by Targeting Both NF-κB and CREB Pathways
por: Grant, Christian, et al.
Publicado: (2006)

Triptolide Inhibits Invasion and Tumorigenesis of Hepatocellular Carcinoma MHCC-97H Cells Through NF-κB Signaling
por: Wang, Haiji, et al.
Publicado: (2016)

Neuroprotection by triptolide against cerebral ischemia/reperfusion injury through the inhibition of NF-κB/PUMA signal in rats
por: Zhang, Bin, et al.
Publicado: (2016)

Triptolide ameliorates fine particulate matter-induced podocytes injury via regulating NF-κB signaling pathway
por: Wan, Qiang, et al.
Publicado: (2020)

Anti‐oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient‐derived tumor xenograft model
por: Yang, Cheng‐Yu, et al.
Publicado: (2018)

Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation
por: Liu, Li, et al.
Publicado: (2014)

Activating transcription factor 3 represses inflammatory responses by binding to the p65 subunit of NF-κB
por: Kwon, Ji-Woong, et al.
Publicado: (2015)

Interplay between Cytokine Circuitry and Transcriptional Regulation Shaping Helper T Cell Pathogenicity and Plasticity in Inflammatory Bowel Disease
por: Fu, Shin-Huei, et al.
Publicado: (2020)

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway
por: Liu, Zi-Miao, et al.
Publicado: (2021)

NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes
por: Huang, Kuo-Hsiung, et al.
Publicado: (2014)

Anti-cancer and Sensibilisation Effect of Triptolide on Human Epithelial Ovarian Cancer
por: Hu, Hui, et al.
Publicado: (2016)

HOXA9 Transcriptionally Promotes Apoptosis and Represses Autophagy by Targeting NF-κB in Cutaneous Squamous Cell Carcinoma
por: Han, Shuo, et al.
Publicado: (2019)

Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines
por: Zuiderwijk-Sick, Ella A., et al.
Publicado: (2021)

4-Hydroxy-17-methylincisterol from Agaricus blazei Decreased Cytokine Production and Cell Proliferation in Human Peripheral Blood Mononuclear Cells via Inhibition of NF-AT and NF-κB Activation
por: Tsai, Wei-Jern, et al.
Publicado: (2013)

Influenza A virus NS1 protein represses antiviral immune response by hijacking NF-κB to mediate transcription of type III IFN
por: Lee, Meng-Chang, et al.
Publicado: (2022)

Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases
por: Hsu, Chao-Yuan, et al.
Publicado: (2020)

NF-κB Signaling in Ovarian Cancer
por: Harrington, Brittney S., et al.
Publicado: (2019)

NF-κB Repression by PIAS3 Mediated RelA SUMOylation
por: Liu, Yuangang, et al.
Publicado: (2012)

Foxp3 Interacts with c-Rel to Mediate NF-κB Repression
por: Loizou, Louiza, et al.
Publicado: (2011)

Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment
por: Yang, Nuo, et al.
Publicado: (2008)

Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells
por: Yang, Cheng-Yu, et al.
Publicado: (2017)

Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway
por: Lin, Yi-Hsuan, et al.
Publicado: (2020)

The Transcription Factor Erg Controls Endothelial Cell Quiescence by Repressing Activity of Nuclear Factor (NF)-κB p65
por: Dryden, Nicola H., et al.
Publicado: (2012)

Triptolide inhibits matrix metalloproteinase-9 expression and invasion of breast cancer cells through the inhibition of NF-κB and AP-1 signaling pathways
por: Hong, On-Yu, et al.
Publicado: (2021)

Discovery of potential targets of Triptolide through inverse docking in ovarian cancer cells
por: Wu, Qinhang, et al.
Publicado: (2020)

Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway
por: Hu, Lanyan, et al.
Publicado: (2023)

Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis
por: Liang, Xia, et al.
Publicado: (2019)

Network pharmacology of triptolide in cancer cells: implications for transcription factor binding
por: Seo, Ean-Jeong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_da5tqtdl77rm3k79tj0v4rqqhi