ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells

Aberrant expression and activation of EGFR and ERBB2 (HER2) have been successfully targeted for cancer therapeutics. Recent evidence from both basic and clinical studies suggests that ERBB3 (HER3) serves as a key activator of downstream signaling through dimerization with other ERBB proteins and pla...

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Detalles Bibliográficos
Autores principales: Choi, Byung-Kwon, Fan, Xuejun, Deng, Hui, Zhang, Ningyan, An, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544427/
https://www.ncbi.nlm.nih.gov/pubmed/23342251
http://dx.doi.org/10.1002/cam4.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544427/
https://www.ncbi.nlm.nih.gov/pubmed/23342251
http://dx.doi.org/10.1002/cam4.10

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