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Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers
DNA methylation, consisting of the addition of a methyl group at the fifth-position of cytosine in a CpG dinucleotide, is one of the most well-studied epigenetic mechanisms in mammals with important functions in normal and disease biology. Disease-specific aberrant DNA methylation is a well-recogniz...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544446/ https://www.ncbi.nlm.nih.gov/pubmed/23342273 http://dx.doi.org/10.1002/cam4.22 |