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A novel monoclonal antibody of human stem cell factor inhibits umbilical cord blood stem cell ex vivo expansion

Stem cell factor (SCF) activates hematopoietic stem cell (HSC) self-renewal and is being used to stimulate the ex vivo expansion of HSCs. The mechanism by which SCF supports expansion of HSCs remains poorly understood. In cord blood ex vivo expansion assays, a newly produced anti-SCF monoclonal anti...

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Detalles Bibliográficos
Autores principales: Fan, Jie, Ding, Xinxin, Jiang, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544603/
https://www.ncbi.nlm.nih.gov/pubmed/23228140
http://dx.doi.org/10.1186/1756-8722-5-73