Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction

BACKGROUND: Although the aggregation of PrP(Sc) is thought to be crucial for the neuropathology of prion diseases, there is evidence in cultured cells and transgenic mice that neuronal death can be triggered by the accumulation of cytosolic PrPs, leading to the hypothesis that the accumulation of Pr...

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Detalles Bibliográficos
Autores principales: Zhang, Jin, Wang, Ke, Guo, Yan, Shi, Qi, Tian, Chan, Chen, Cao, Gao, Chen, Zhang, Bao-Yun, Dong, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544727/
https://www.ncbi.nlm.nih.gov/pubmed/23216755
http://dx.doi.org/10.1186/1743-422X-9-303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544727/
https://www.ncbi.nlm.nih.gov/pubmed/23216755
http://dx.doi.org/10.1186/1743-422X-9-303

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