Mutations in the Fusion Protein Cleavage Site of Avian Paramyxovirus Serotype 4 Confer Increased Replication and Syncytium Formation In Vitro but Not Increased Replication and Pathogenicity in Chickens and Ducks

To evaluate the role of the F protein cleavage site in the replication and pathogenicity of avian paramyxoviruses (APMVs), we constructed a reverse genetics system for recovery of infectious recombinant APMV-4 from cloned cDNA. The recovered recombinant APMV-4 resembled the biological virus in growt...

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Detalles Bibliográficos
Autores principales: Kim, Shin-Hee, Xiao, Sa, Shive, Heather, Collins, Peter L., Samal, Siba K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544850/
https://www.ncbi.nlm.nih.gov/pubmed/23341874
http://dx.doi.org/10.1371/journal.pone.0050598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544850/
https://www.ncbi.nlm.nih.gov/pubmed/23341874
http://dx.doi.org/10.1371/journal.pone.0050598

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