Differential Processing of let-7a Precursors Influences RRM2 Expression and Chemosensitivity in Pancreatic Cancer: Role of LIN-28 and SET Oncoprotein

Overexpression of ribonucleotide reductase subunit M2 (RRM2), involved in deoxyribonucleotide synthesis, drives the chemoresistance of pancreatic cancer to nucleoside analogs (e.g., gemcitabine). While silencing RRM2 by synthetic means has shown promise in reducing chemoresistance, targeting endogen...

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Detalles Bibliográficos
Autores principales: Bhutia, Yangzom Doma, Hung, Sau Wai, Krentz, Madeline, Patel, Dimal, Lovin, Dylan, Manoharan, Radhika, Thomson, J. Michael, Govindarajan, Rajgopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546076/
https://www.ncbi.nlm.nih.gov/pubmed/23335963
http://dx.doi.org/10.1371/journal.pone.0053436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546076/
https://www.ncbi.nlm.nih.gov/pubmed/23335963
http://dx.doi.org/10.1371/journal.pone.0053436

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