An analysis and validation pipeline for large-scale RNAi-based screens

Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a large-scale pooled shRNA screen in mouse embryonic stem cells (ESCs) to discover genes associated with oxidative stress r...

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Detalles Bibliográficos
Autores principales: Plank, Michael, Hu, Guang, Silva, A. Sofia, Wood, Shona H., Hesketh, Emily E., Janssens, Georges, Macedo, André, de Magalhães, João Pedro, Church, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546318/
https://www.ncbi.nlm.nih.gov/pubmed/23326633
http://dx.doi.org/10.1038/srep01076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546318/
https://www.ncbi.nlm.nih.gov/pubmed/23326633
http://dx.doi.org/10.1038/srep01076

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