Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena. Experiments...

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Detalles Bibliográficos
Autores principales: Ding, Zufeng, Liu, Shijie, Wang, Xianwei, Khaidakov, Magomed, Dai, Yao, Mehta, Jawahar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546319/
https://www.ncbi.nlm.nih.gov/pubmed/23326634
http://dx.doi.org/10.1038/srep01077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546319/
https://www.ncbi.nlm.nih.gov/pubmed/23326634
http://dx.doi.org/10.1038/srep01077

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