Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site

Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) cause lower respiratory infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody resp...

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Detalles Bibliográficos
Autores principales: Wen, Xiaolin, Krause, Jens C., Leser, George P., Cox, Reagan G., Lamb, Robert A., Williams, John, Crowe, James E., Jardetzky, Theodore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546531/
https://www.ncbi.nlm.nih.gov/pubmed/22388735
http://dx.doi.org/10.1038/nsmb.2250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546531/
https://www.ncbi.nlm.nih.gov/pubmed/22388735
http://dx.doi.org/10.1038/nsmb.2250

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