Discovery of Novel Focal Adhesion Kinase Inhibitors Using a Hybrid Protocol of Virtual Screening Approach Based on Multicomplex-Based Pharmacophore and Molecular Docking

Focal adhesion kinase (FAK) is a tyrosine kinase that functions as a key orchestrator of signals leading to invasion and metastasis. In the current study, the multicomplex-based pharmacophore (MCBP)-guided method has been suggested to generate a comprehensive pharmacophore of FAK kinase based on sev...

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Detalles Bibliográficos
Autores principales: Wu, Fengbo, Xu, Ting, He, Gu, Ouyang, Liang, Han, Bo, Peng, Cheng, Song, Xiangrong, Xiang, Mingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546655/
https://www.ncbi.nlm.nih.gov/pubmed/23443087
http://dx.doi.org/10.3390/ijms131215668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546655/
https://www.ncbi.nlm.nih.gov/pubmed/23443087
http://dx.doi.org/10.3390/ijms131215668

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