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Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

Drug metabolism in human liver is a process involving many different enzymes. Among them, a number of cytochromes P450 isoforms catalyze the oxidation of most of the drugs commercially available. Each P450 isoform acts on more than one drug, and one drug may be oxidized by more than one enzyme. As a...

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Detalles Bibliográficos
Autores principales: Di Nardo, Giovanna, Gilardi, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546669/
https://www.ncbi.nlm.nih.gov/pubmed/23443101
http://dx.doi.org/10.3390/ijms131215901