Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

BACKGROUND: The α-isoform of the Type 1A Phosphoinositide 3-kinases (PI3Kα) has protein kinase activity as well as phosphoinositide lipid kinase activity. The best described substrate for its protein kinase activity is its regulatory subunit, p85α, which becomes phosphorylated on Serine 608. Phospho...

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Detalles Bibliográficos
Autores principales: Layton, Meredith J, Saad, Mirette, Church, Nicole L, Pearson, Richard B, Mitchell, Christina A, Phillips, Wayne A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546864/
https://www.ncbi.nlm.nih.gov/pubmed/23270540
http://dx.doi.org/10.1186/1471-2091-13-30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546864/
https://www.ncbi.nlm.nih.gov/pubmed/23270540
http://dx.doi.org/10.1186/1471-2091-13-30

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