Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

BACKGROUND: 5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes and 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (oxoETE). These inflammatory signaling molecules play a role in the pathology of asthma and so 5-LO inhibition is a promising target for asthma therapy. The 5-LO redox inh...

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Detalles Bibliográficos
Autores principales: Karelina, Tatiana A, Zhudenkov, Kirill V, Demin, Oleg O, Svetlichny, Dmitry V, Agoram, Balaji, Fairman, David, Demin, Oleg V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546923/
https://www.ncbi.nlm.nih.gov/pubmed/23146124
http://dx.doi.org/10.1186/1752-0509-6-141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546923/
https://www.ncbi.nlm.nih.gov/pubmed/23146124
http://dx.doi.org/10.1186/1752-0509-6-141

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