Cargando…

Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

BACKGROUND: 5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes and 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (oxoETE). These inflammatory signaling molecules play a role in the pathology of asthma and so 5-LO inhibition is a promising target for asthma therapy. The 5-LO redox inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karelina, Tatiana A, Zhudenkov, Kirill V, Demin, Oleg O, Svetlichny, Dmitry V, Agoram, Balaji, Fairman, David, Demin, Oleg V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546923/ https://www.ncbi.nlm.nih.gov/pubmed/23146124 http://dx.doi.org/10.1186/1752-0509-6-141

Ejemplares similares

Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic-Pharmacodynamic Behavior: An Example Using 5-Lipoxygenase Inhibitors
por: Demin, O, et al.
Publicado: (2013)

A Mathematical Modeling Approach to Understanding the Effect of Anti‐Interleukin Therapy on Eosinophils
por: Karelina, T, et al.
Publicado: (2016)

A mathematical model of multisite phosphorylation of tau protein
por: Stepanov, Alexander, et al.
Publicado: (2018)

Correction: A mathematical model of multisite phosphorylation of tau protein
por: Stepanov, Alexander, et al.
Publicado: (2018)

Studying the Progression of Amyloid Pathology and Its Therapy Using Translational Longitudinal Model of Accumulation and Distribution of Amyloid Beta
por: Karelina, Tatiana, et al.
Publicado: (2017)

The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury
por: Rossi, Antonietta, et al.
Publicado: (2007)

EI of the Phosphotransferase System of Escherichia coli: Mathematical Modeling Approach to Analysis of Its Kinetic Properties
por: Karelina, T. A., et al.
Publicado: (2011)

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis
por: Boudreau, Luc H., et al.
Publicado: (2017)

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A(4) Hydrolase
por: Teder, Tarvi, et al.
Publicado: (2023)

The role of leukotriene inhibition using a 5-lipoxygenase (5-LO) inhibitor in a joint contracture model
por: Jeffs, Alexander D., et al.
Publicado: (2023)

Monoclonal antibody therapy efficacy can be boosted by combinations with other treatments: Predictions using an integrated Alzheimer’s Disease Platform
por: Karelina, Tatiana, et al.
Publicado: (2021)

Analysis of the efficacy of SGLT2 inhibitors using semi-mechanistic model
por: Demin, Oleg, et al.
Publicado: (2014)

Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B(4) pathway by high-density lipoprotein in macrophages
por: Tsuda, Shigeyasu, et al.
Publicado: (2017)

Differential impact of 5-lipoxygenase-activating protein antagonists on the biosynthesis of leukotrienes and of specialized pro-resolving mediators
por: Dahlke, Philipp, et al.
Publicado: (2023)

Regulation of 5-oxo-ETE synthesis by nitric oxide in human polymorphonuclear leucocytes upon their interaction with zymosan and Salmonella typhimurium
por: Viryasova, Galina M., et al.
Publicado: (2014)

Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling
por: Horn, Thomas, et al.
Publicado: (2015)

Involvement of 5-lipoxygenase/cysteinyl leukotriene receptor 1 in rotenone- and MPP+-induced BV2 microglial activation
por: Wang, Yanfang, et al.
Publicado: (2012)

Human CMV infection induces 5-lipoxygenase expression and leukotriene B(4) production in vascular smooth muscle cells
por: Qiu, Hong, et al.
Publicado: (2008)

Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways
por: Cui, Zhi-Hua, et al.
Publicado: (2012)

Substituted 1,2,4-Triazoles as Novel and Selective Inhibitors of Leukotriene Biosynthesis Targeting 5-Lipoxygenase-Activating Protein
por: Olğaç, Abdurrahman, et al.
Publicado: (2023)

Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study
por: Shchelokov, Dmitry, et al.
Publicado: (2022)

Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201
por: Kretzer, Christian, et al.
Publicado: (2022)

Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1
por: Huang, Xue-Qin, et al.
Publicado: (2012)

5-Lipoxygenase Activating Protein (FLAP) Dependent Leukotriene Biosynthesis Inhibition (MK591) Attenuates Lipid A Endotoxin-Induced Inflammation
por: Fang, Wen-Feng, et al.
Publicado: (2014)

5-Lipoxygenase-mediated Endogenous DNA Damage
por: Jian, Wenying, et al.
Publicado: (2009)

miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells
por: Iacona, Joseph R., et al.
Publicado: (2018)

Modeling of celiac disease immune response and the therapeutic effect of potential drugs
por: Demin, Oleg O, et al.
Publicado: (2013)

Ceramide kinase regulates acute wound healing by suppressing 5-oxo-ETE biosynthesis and signaling via its receptor OXER1
por: Maus, Kenneth D., et al.
Publicado: (2022)

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes
Publicado: (1993)

Roles of 5-Lipoxygenase and Cysteinyl-Leukotriene Type 1 Receptors in the Hematological Response to Allergen Challenge and Its Prevention by Diethylcarbamazine in a Murine Model of Asthma
por: Masid-de-Brito, Daniela, et al.
Publicado: (2014)

A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human
por: Karelina, T, et al.
Publicado: (2017)

5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation
por: Magi, Shigeyuki, et al.
Publicado: (2014)

P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis
por: Dar, Haider H., et al.
Publicado: (2022)

DBSolve Optimum: a software package for kinetic modeling which allows dynamic visualization of simulation results
por: Gizzatkulov, Nail M, et al.
Publicado: (2010)

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
por: Gheorghe, Karina Roxana, et al.
Publicado: (2009)

Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions
por: Kumar, Ramakrishnan B., et al.
Publicado: (2020)

The application of mathematical modelling to the design of bispecific monoclonal antibodies
por: van Steeg, Tamara J., et al.
Publicado: (2016)

Courrier CERN Volume 38, N° 5, Été 1998
por: CERN
Publicado: (1998)

A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics
por: Zhudenkov, Kirill, et al.
Publicado: (2022)

Data on expression of lipoxygenases-5 and -12 in the normal and acetaminophen-damaged liver
por: Suciu, Maria, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lbjmib3k89tms0ksdfja03e4gt