High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

In diabetes, some of the cellular changes are similar to aging. We hypothesized that hyperglycemia accelerates aging-like changes in the endothelial cells (ECs) and tissues leading to structural and functional damage. We investigated glucose-induced aging in 3 types of ECs using senescence associate...

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Detalles Bibliográficos
Autores principales: Mortuza, Rokhsana, Chen, Shali, Feng, Biao, Sen, Subhrojit, Chakrabarti, Subrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546959/
https://www.ncbi.nlm.nih.gov/pubmed/23342163
http://dx.doi.org/10.1371/journal.pone.0054514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546959/
https://www.ncbi.nlm.nih.gov/pubmed/23342163
http://dx.doi.org/10.1371/journal.pone.0054514

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