The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein

Mechanisms for cooperation between the cytosolic Hsp70 system and the ubiquitin proteasome system during protein triage are not clear. Herein, we identify new mechanisms for selection of misfolded cytosolic proteins for degradation via defining functional interactions between specific cytosolic Hsp7...

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Detalles Bibliográficos
Autores principales: Summers, Daniel W., Wolfe, Katie J., Ren, Hong Yu, Cyr, Douglas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547041/
https://www.ncbi.nlm.nih.gov/pubmed/23341891
http://dx.doi.org/10.1371/journal.pone.0052099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547041/
https://www.ncbi.nlm.nih.gov/pubmed/23341891
http://dx.doi.org/10.1371/journal.pone.0052099

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