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A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields
A long-standing paradigm in B cell immunology is that effective somatic hypermutation and affinity maturation require cycling between the dark zone and light zone of the germinal center. The cyclic re-entry hypothesis was first proposed based on considerations of the efficiency of affinity maturatio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547247/ https://www.ncbi.nlm.nih.gov/pubmed/23296998 http://dx.doi.org/10.1007/s11538-012-9799-9 |