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Loss of HPV16 E2 Protein Expression Without Disruption of the E2 ORF Correlates with Carcinogenic Progression

Integration of the viral DNA in the cellular genome has been suggested to be critical in carcinogenic progression of HPV-associated cervical neoplasia. This event can be accompanied by disruption of the open reading frame (ORF) encoding the E2 repressor, thus leading to transcriptional up-regulation...

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Detalles Bibliográficos
Autores principales: Xue, Yuezhen, Lim, Diana, Zhi, Liang, He, Pingping, Abastado, Jean-Pierre, Thierry, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547325/
https://www.ncbi.nlm.nih.gov/pubmed/23341852
http://dx.doi.org/10.2174/1874357901206010163