Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin

Ankyrin repeat proteins are elastic materials that unfold and refold sequentially, repeat by repeat, under force. Herein we use atomistic molecular dynamics to compare the mechanical properties of the 7-ankyrin-repeat oncoprotein Gankyrin in isolation and in complex with its binding partner S6-C. We...

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Detalles Bibliográficos
Autores principales: Settanni, Giovanni, Serquera, David, Marszalek, Piotr E., Paci, Emanuele, Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547791/
https://www.ncbi.nlm.nih.gov/pubmed/23341763
http://dx.doi.org/10.1371/journal.pcbi.1002864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547791/
https://www.ncbi.nlm.nih.gov/pubmed/23341763
http://dx.doi.org/10.1371/journal.pcbi.1002864

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