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Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin
Ankyrin repeat proteins are elastic materials that unfold and refold sequentially, repeat by repeat, under force. Herein we use atomistic molecular dynamics to compare the mechanical properties of the 7-ankyrin-repeat oncoprotein Gankyrin in isolation and in complex with its binding partner S6-C. We...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547791/ https://www.ncbi.nlm.nih.gov/pubmed/23341763 http://dx.doi.org/10.1371/journal.pcbi.1002864 |