Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice

Prader-Willi Syndrome is the most common syndromic form of human obesity and is caused by the loss of function of several genes, including MAGEL2. Mice lacking Magel2 display increased weight gain with excess adiposity and other defects suggestive of hypothalamic deficiency. We demonstrate Magel2-nu...

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Detalles Bibliográficos
Autores principales: Mercer, Rebecca E., Michaelson, Sheldon D., Chee, Melissa J. S., Atallah, Tanya A., Wevrick, Rachel, Colmers, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547795/
https://www.ncbi.nlm.nih.gov/pubmed/23341784
http://dx.doi.org/10.1371/journal.pgen.1003207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547795/
https://www.ncbi.nlm.nih.gov/pubmed/23341784
http://dx.doi.org/10.1371/journal.pgen.1003207

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