The Immunosuppressive Agent Mizoribine Monophosphate Is an Inhibitor of the Human RNA Capping Enzyme

Mizoribine monophosphate (MZP) is a specific inhibitor of the cellular inosine-5′-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the rate-limiting step of de novo guanine nucleotide biosynthesis. MZP is a highly potent antagonistic inhibitor of IMPDH that blocks the proliferation of T an...

Descripción completa

Detalles Bibliográficos
Autores principales: Picard-Jean, Frédéric, Bougie, Isabelle, Shuto, Satoshi, Bisaillon, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547949/
https://www.ncbi.nlm.nih.gov/pubmed/23349942
http://dx.doi.org/10.1371/journal.pone.0054621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547949/
https://www.ncbi.nlm.nih.gov/pubmed/23349942
http://dx.doi.org/10.1371/journal.pone.0054621

Ejemplares similares