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The Immunosuppressive Agent Mizoribine Monophosphate Is an Inhibitor of the Human RNA Capping Enzyme

Mizoribine monophosphate (MZP) is a specific inhibitor of the cellular inosine-5′-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the rate-limiting step of de novo guanine nucleotide biosynthesis. MZP is a highly potent antagonistic inhibitor of IMPDH that blocks the proliferation of T an...

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Detalles Bibliográficos
Autores principales:	Picard-Jean, Frédéric, Bougie, Isabelle, Shuto, Satoshi, Bisaillon, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547949/ https://www.ncbi.nlm.nih.gov/pubmed/23349942 http://dx.doi.org/10.1371/journal.pone.0054621

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