Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9

Notch signaling plays a critical role during development by directing the binary cell fate decision between progenitors and differentiated cells. Previous studies have shown sustained Notch activation in cartilage leads to chondrodysplasia. Genetic evidence indicates that Notch regulates limb bud me...

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Detalles Bibliográficos
Autores principales: Chen, Shan, Tao, Jianning, Bae, Yangjin, Jiang, Ming-Ming, Bertin, Terry, Chen, Yuqing, Yang, Tao, Lee, Brendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548081/
https://www.ncbi.nlm.nih.gov/pubmed/22991339
http://dx.doi.org/10.1002/jbmr.1770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548081/
https://www.ncbi.nlm.nih.gov/pubmed/22991339
http://dx.doi.org/10.1002/jbmr.1770

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