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Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9
Notch signaling plays a critical role during development by directing the binary cell fate decision between progenitors and differentiated cells. Previous studies have shown sustained Notch activation in cartilage leads to chondrodysplasia. Genetic evidence indicates that Notch regulates limb bud me...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548081/ https://www.ncbi.nlm.nih.gov/pubmed/22991339 http://dx.doi.org/10.1002/jbmr.1770 |