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The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response

The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the expression of molecular chaperones. SIRT1 has...

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Detalles Bibliográficos
Autores principales: Raynes, Rachel, Pombier, Kathleen M., Nguyen, Kevin, Brunquell, Jessica, Mendez, Jamie E., Westerheide, Sandy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548779/
https://www.ncbi.nlm.nih.gov/pubmed/23349863
http://dx.doi.org/10.1371/journal.pone.0054364