γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production

γ-Secretase cleaves the carboxyl-terminal fragment (βCTF) of APP not only in the middle of the transmembrane domain (γ-cleavage), but also at sites close to the membrane/cytoplasm boundary (ε-cleavage), to produce the amyloid β protein (Aβ) and the APP intracellular domain (AICD), respectively. The...

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Detalles Bibliográficos
Autores principales: Takami, Mako, Funamoto, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549393/
https://www.ncbi.nlm.nih.gov/pubmed/23346458
http://dx.doi.org/10.1155/2012/591392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549393/
https://www.ncbi.nlm.nih.gov/pubmed/23346458
http://dx.doi.org/10.1155/2012/591392

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