p27(Kip1) Directly Represses Sox2 during Embryonic Stem Cell Differentiation

The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly...

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Detalles Bibliográficos
Autores principales: Li, Han, Collado, Manuel, Villasante, Aranzazu, Matheu, Ander, Lynch, Cian J., Cañamero, Marta, Rizzoti, Karine, Carneiro, Carmen, Martínez, Gloria, Vidal, Anxo, Lovell-Badge, Robin, Serrano, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549496/
https://www.ncbi.nlm.nih.gov/pubmed/23217425
http://dx.doi.org/10.1016/j.stem.2012.09.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549496/
https://www.ncbi.nlm.nih.gov/pubmed/23217425
http://dx.doi.org/10.1016/j.stem.2012.09.014

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