The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

B cell development requires tight regulation to allow for the generation of a diverse repertoire while preventing the development of autoreactive cells. We report, using N-ethyl-N-nitrosourea (ENU)–induced mutagenesis, the identification of a mutant mouse (chompB) with a block in early B cell develo...

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Detalles Bibliográficos
Autores principales: Beisner, Daniel R., Langerak, Petra, Parker, Albert E., Dahlberg, Carol, Otero, Francella J., Sutton, Sue E., Poirot, Laurent, Barnes, Whitney, Young, Michael A., Niessen, Sherry, Wiltshire, Tim, Bodendorf, Ursula, Martoglio, Bruno, Cravatt, Benjamin, Cooke, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549714/
https://www.ncbi.nlm.nih.gov/pubmed/23267013
http://dx.doi.org/10.1084/jem.20121072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549714/
https://www.ncbi.nlm.nih.gov/pubmed/23267013
http://dx.doi.org/10.1084/jem.20121072

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