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The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain
B cell development requires tight regulation to allow for the generation of a diverse repertoire while preventing the development of autoreactive cells. We report, using N-ethyl-N-nitrosourea (ENU)–induced mutagenesis, the identification of a mutant mouse (chompB) with a block in early B cell develo...
Autores principales: | Beisner, Daniel R., Langerak, Petra, Parker, Albert E., Dahlberg, Carol, Otero, Francella J., Sutton, Sue E., Poirot, Laurent, Barnes, Whitney, Young, Michael A., Niessen, Sherry, Wiltshire, Tim, Bodendorf, Ursula, Martoglio, Bruno, Cravatt, Benjamin, Cooke, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549714/ https://www.ncbi.nlm.nih.gov/pubmed/23267013 http://dx.doi.org/10.1084/jem.20121072 |
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