The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease

BACKGROUND: Chemokine receptor CXCR4, together with its ligand CXCL12, plays critical roles in cancer progression, including growth, metastasis and angiogenesis. Ewing sarcoma is a sarcoma with poor prognosis despite current therapies, particularly for patients with advanced-stage disease. Lungs and...

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Detalles Bibliográficos
Autores principales: Berghuis, Dagmar, Schilham, Marco W, Santos, Susy J, Savola, Suvi, Knowles, Helen J, Dirksen, Uta, Schaefer, Karl-Ludwig, Vakkila, Jukka, Hogendoorn, Pancras CW, Lankester, Arjan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549731/
https://www.ncbi.nlm.nih.gov/pubmed/23249693
http://dx.doi.org/10.1186/2045-3329-2-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549731/
https://www.ncbi.nlm.nih.gov/pubmed/23249693
http://dx.doi.org/10.1186/2045-3329-2-24

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